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Buy prozac 20 mg and placebo for 12 weeks. Protonix/Dronabinol was used for both treatment arms. Patients in the high-dose arm also received placebo for the Prozac 30 Pills 20mg $39 - $1.3 Per pill first week. On Day 9, the placebo group had significantly more nausea and vomiting than did those in the high-dose group. A follow-up analysis showed the addition of placebo to high-dose group lowered the number of patients who experienced significant nausea and vomiting by 27 percent, compared with a 36 percent reduction in those taking both placebo and plus protonix/dronabinol. "The addition of placebo to the high-dose group was more effective than the addition of placebo alone in reducing the number of patients who experienced significant nausea and vomiting," says the study's senior author, Jeffrey A. Smith, PhD, from the Yale University School of Medicine. In addition, all four of the patients in high-dose group had a significant reduction in anxiety, compared with four of six patients in the placebo group. The results suggest that addition of a small dose protonix/dronabinol could provide some pain relief to healthy patients, says Dr. Smith. "I believe that adding placebo in high doses to protonix/dronabinol could be used as a potential mechanism for the anti-nausea effect or as a potential therapeutic approach for the management of postoperative nausea and vomiting," he says. The study involved 16 patients: 13 in the placebo group and four in the protonix/dronabinol group. All were healthy and free of psychiatric disorders, cardiovascular disease, and cancer. "Many people suffer with nausea and vomiting following procedures, so it's important to have options for pain relief," says Dr. Smith. "The addition of placebo to protonix/dronabinol could be a very effective way to provide relief these patients." The Yale group has now conducted a trial involving larger group of 16 patients, and will publish their results later in the year. The study was funded by National Institutes of Health, the Cancer Institute, and National Institute of Diabetes Digestive and Kidney Diseases. Dr. Smith is also affiliated with the Yale Clinical Research Institute in New Haven, Conn. Presentation: "A Novel Approach to Pain Treatment in Patients With Postoperative Nausea and Vomiting," Jeffrey A. Smith, PhD, et al, in Annals of the New York Academy Sciences (December 7, 2012) Additional Information For more information, contact the Johns Hopkins University School of Medicine Public Affairs Office at 410-857-1518.

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